Melatonin and Coronary Artery Calcification

Association Between Plasma Melatonin and Coronary Artery Calcification

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03967366

Enrollment

574

Registered

2019-05-30

Start date

2017-05-01

Completion date

2019-04-30

Last updated

2019-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Calcification

Keywords

Melatonin, coronary artery calcification, relation

Brief summary

The investigators planned to research the association between plasma melatonin and coronary artery calcification in a Chinese population.

Detailed description

Coronary artery calcification (CAC) is prevalent in coronary artery disease (CHD), and the extent of CAC predicts cardiovascular risk. The causes of CAC include dysregulated matrix metabolism, epitaxial mineral deposition, inflammation, oxidative stress, and apoptosis. Melatonin is the main indoleamine produced by the pineal gland; it is known recently to have anti-inflammatory, anti-cancer and antioxidant activities. Several studies have shown that melatonin protects against inflammation and apoptosis in vascular calcification. Melatonin also inhibits oxidative stress-induced apoptosis and calcification in endplate chondrocytes. However, no study has evaluated whether melatonin is associated with CAC in patients with coronary atherosclerosis. The investigators planned to research the association between plasma melatonin and coronary artery calcification.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Inclusion criteria

Patients with angina-like chest pain, were included in this study. All subjects had blood samples collected and all underwent a coronary CTA scan.

Exclusion criteria

1. melatonin treatment 2. coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery) 3. heart failure or cardiomyopathies 4. hepatic failure 5. renal dysfunction 6. haemolytic disorders 7. thyroid disease 8. neoplastic diseases 9. acute infectious or inflammatory conditions.

Design outcomes

Primary

Measure	Time frame	Description
correlations of CAC score with melatonin concentrations	Subjects underwent a CAC scan at baseline.	CAC score was obtained using the coronary CTA and Agatston score.

Secondary

Measure	Time frame	Description
correlations of CAC score with high-sensitivity C-reactive protein (hsCRP) level	Subjects had blood samples collected at baseline.	The hsCRP levels were analyzed by a sandwich enzyme linked immunosorbent assay.
correlations of CAC score with malondialdehyde (MDA) level	Subjects had blood samples collected at baseline.	The MDA levels were analyzed by a sandwich enzyme linked immunosorbent assay.

Countries

China

Outcome results