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Risk Factors for Major Complications After Liver Resection

Risk Factors for Major Complications After Liver Resection: Audit of a Non-Eastern/Non-Western Experience

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03967067
Enrollment
213
Registered
2019-05-30
Start date
2010-01-01
Completion date
2016-12-31
Last updated
2019-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Diseases

Keywords

Audit, Liver resection, Surgical complications, non-Eastern/non-Western, Quality improvement

Brief summary

The aim of this study is to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Detailed description

Over the past 20 years, the refinement of liver surgery techniques, anesthesiology and perioperative management has dramatically improved the safety of liver resection patients. It has also led to a concomitant extension of indications for a growing number of patients with complex benign or malignant hepatobiliary diseases and/or high risk surgeries. Published complication rates and risk prediction models and recommendations for patients undergoing liver resection primarily stem from far East or Western high-volume specialized centers. In developing countries, including those in North Africa, specific constraints (e.g., endemic indications, such as liver cystic hydatidosis, blood shortage, and the scarcity of liver surgeons and intensive care providers) may impact liver resection outcomes but they are rarely addressed in the literature. The aim of this study was to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Interventions

PROCEDUREliver resection

Open or laparoscopic, major or minor hepatectomy performed using the clamp-crush technique and intermittent clamping of hepatic pedicle

Sponsors

Moroccan Society of Surgery
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* all patients who underwent an hepatectomy * between january 2010 and December 2015

Exclusion criteria

* All patient who only underwent liver biopsy with no resection * Patients non operated

Design outcomes

Primary

MeasureTime frameDescription
90-day Mortality rate90 days from surgeryDeath within 90 days of surgical procedure
90-day Complication rate90 days from surgeryDefined by Clavien-Dindo grade I to IV within90 days of surgical procedure

Secondary

MeasureTime frameDescription
Risk factor of major complication at 90-day90 days from surgerydefined by multivariate logistic regression of 90 day complication with Clavien-Dindo more than grade III

Countries

Morocco

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026