Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal Injection of Platelet-rich Plasma (PRP)

Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03966638

Acronym

COMPARE

Enrollment

Registered

2019-05-29

Start date

2017-11-01

Completion date

2020-11-30

Last updated

2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Meniscus Lesion

Brief summary

Meniscal lesions are a common pathology among athletes, and have an impact on the daily or sporting practice of patients. The consequences of surgical treatment are sometimes heavy. Platelet-rich-plasma (PRP) has been shown to be effective in healing tendon and ligament lesions. PRP has been injected under ultrasound in tendons or intra-articularly for several years. This technique of meniscal percutaneous injection of PRP is now carried out for more than 2 years in our hospital, with satisfactory preliminary results, without any complication. All patients in our study received an intra-meniscal injection of PRP, under echographic control. They were evaluated clinically and by Magnetic Resonance Imaging (MRI) before and at 6 months of the injection. The aim of the study is to evaluate the efficacy of intra-meniscal injection of PRP on the symptomatology of the patients (pain, sport activities and daily life) at 6 months post-treatment.

Interventions

PROCEDUREIntra-meniscal injection of platelet-rich plasma

Intra-meniscal injection of platelet-rich plasma under echographic control

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* isolated symptomatic meniscal lesion * lesion confirmed by MRI * grade II or III lesion touching the peripheral involvement of the middle segment, * lesion treated by percutaneous intra meniscal PRP's injection * IKDC score measured before injection and 6 months post-injection

Exclusion criteria

* other painful etiology of the knee * emergency surgical management (luxation, bucket handle) or not (indication validated by the surgeon, meniscectomy or meniscal suture) * impossibility to perform the procedure (non visible lesion, morphology of the patient, cutaneous infection, coagulation treatment in progress)

Design outcomes

Primary

Measure	Time frame	Description
Variation of International Knee Documentation Committee (IKDC) score	Between 0 and 6 months post injection	The variation of IKDC score between before injection and 6 months post-injection will be calculated. The IKDC score ranges from 0 to 100 and is interpreted as a measure of function with higher scores representing higher levels of function.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026