Reminerlization Potential of GSE Gel versusCPP-ACP in Carious White Spot Lesions in Post Orthodontic Patients

Reminerlization Potential of Grape Seeds Extract Gel Versus Casein Phosphopeptide-amorphous Calcium Phosphate in Carious White Spot Lesions in Post Orthodontic Patients

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03966378

Enrollment

Registered

2019-05-29

Start date

2019-10-03

Completion date

2020-05-10

Last updated

2019-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Brief summary

Assess the effectiveness of applying grape seed extract (GSE) gel versus casein phosphopeptide-amorphous calcium phosphate (MI) paste on remineralization of white spot lesion (WSLs) in post orthodontic patients.

Detailed description

The development of WSLs is a challenging problem in the track of orthodontic treatment. Especially in patients wearing fixed orthodontic appliances, plaque accumulation increases around brackets and bands and the pH on dental surfaces becomes acidic. These early lesions are willing to remineralization, arrest, reharden and revert to healthy enamel condition through a remineralization process involving the diffusion of minerals into the defective tooth structure. For this purpose various remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and grape seed extract (GSE) have been used. This research is conducted for early intervention and treatment of the white spot lesions by non-invasive method.

Interventions

OTHERGrape seeds extract

Grape seeds extract powder

OTHERCasein-phosphopeptide/amorphous-calcium phosphate

CPP-ACP paste

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

13 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Presence of at least two WSLs on the labial surfaces of six maxillary anterior teeth that were not present before orthodontic therapy.

Exclusion criteria

* Severe or active periodontal disease. * Patients had received therapeutic irradiation to the head and neck region. * Patients had participated in a clinical trial within 6 months before commencement of this trial. * Patients unable to return for recall appointments * Presence of abnormal oral, medical, or mental condition (including any milk-related allergies or any medical condition involving kidneys or salivary glands). * Presence of restorations or cavities in any anterior teeth or enamel hypoplasia, dental fluorosis, or intrinsic and extrinsic pigmentation.

Design outcomes

Primary

Measure	Time frame	Description
Quantitative changes of white spot lesions	evaluation of tooth surface changes at baseline and at 4, 12, and 24 weeks after starting treatment .	changes in fluorescence of white spot lesions will be evaluated after reminerlization by using diagnodent device by score (0-20).

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026