Bone Remodeling, Healthy, Incretins, Osteoporosis
Conditions
Brief summary
The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is unknown. The serum incretin concentration is low and increases rapidly after a meal. This increase is brief, incretins being rapidly degraded by dipeptidylpeptidase 4 (DPP-4). The dosage of these hormones is complex and the basal normal serum concentrations and after feeding in healthy subjects are unknown. Before any study on the effect of incretins on bone remodeling in humans, it is necessary to establish physiological concentrations of incretins in healthy subjects. The aim of this study is to estimate physiological concentrations of incretins in healthy subject.
Interventions
OTHERblood sample
we perform blood sample in healthy subject before and after a meal to measure incretins concentration
Sponsors
University Hospital, Angers
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy women and men
Exclusion criteria
* known osteoporosis * osteoporotic fracture * tobacco * alcohol : \> 2 glasses/day * type 1 and type 2 diabetes * BMI \< 19kg/m² or \> 30kg/m² * heart failure, kidney failure * cancer * bariatric surgery * graft * cirrhosis * use in the past year : bisphosphonate, denosumab, raloxifene, teriparatide, oral or IV glucocorticoid during 3 months or more
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incretins concentrations before and after a meal in healthy subjects | 2 years |
Countries
France
Outcome results
None listed