Central Auditory Processing Disorder, Unilateral Vocal Cord Paralysis
Conditions
Brief summary
The purpose of this preliminary study is to help clarify our hypotheses for the longitudinal study by investigating the relationship between vocal cord paralysis and central auditory processes and thus the interpretation of auditory inputs into the central nervous system.
Detailed description
A very recent study (Naunheim et al., 2018) shows that paralysis of a vocal cord can affect central auditory processes, which in turn would have a negative impact on motor control capabilities during voice production. This study was conducted in patients who had undergone Type I thyroplasty. To highlight these influences, the authors relied on behavioral tests of auditory perception and vocal production. The investigators would like in this study, based on a similar and existing population at the Cliniques Universitaires Saint-Luc, to try to understand the changes observed clinically by proposing to perform vocal production tasks (also planned for the longitudinal study) in the MRI. The investigators would like to objectify the differences in the areas involved in the central auditory processes in comparison between patients and control subjects.
Interventions
None listed
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Unilateral paralysis in abduction of the vocal cords may be included in the study. * Patients who undergone type I thyroplasty (with Montgomery implant) at least 3 months ago * Control participants without voice disorder
Exclusion criteria
* Wear a pacemaker or other implanted devices (prostheses ...). * Wear metal clips, metal in the head, or an adjustable brain drain. * Wear non-removable dental appliances (except fillings). * Wear cardiac valve prostheses. * Have worked the metals. * Have a tattoo containing metal particles. * Have implanted jewelry (e.g., piercing). * Being prone to epileptic seizures. * Take medications that alter cortical excitability. * Have had a brain surgery. * Suffer from intracranial hypertension. * Be pregnant or breastfeeding recently. * Present allergies that are incompatible with the experimental protocol. * Have an abnormal hearing loss in view of their age, identified with tonal and / or vocal audiometry.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Voice quality | Min 3 months post thyroplasty | Multidimensional voice assessment (Anamnestic interview, Maximum Phonation Time, Mean Air Flow, Mean subglottic pressure, Jitter, Shimmer, Noise-to-harmonic ratio, phonetogram, smoothed cepstral peak prominence, Voice Handicap Index - VHI-30, SF-36, EAT-10, GRBAS-I, Acoustic Voice Quality Index, Dysphonia Severity Index, Tonal and vocal audiometries) |
| Changes in the neuronal pathways involved in the processing of the auditory inputs | Max 6 months after involvement in the study | Functional magnetic resonance imaging examination (tomodensitometry and connectivity) |
| Central auditory processes | Min 3 months post thyroplasty | Auditory perception tasks performed using an audio headset (sound detection in noise, localization of a sound source, dichotic listening test, masking test, duration and frequency pattern test) |
Countries
Belgium
Outcome results
None listed