Abdominal Hysterectomy
Conditions
Keywords
vitamin c, Hysterectomy, bleeding, wound healing, abdominal surgeries
Brief summary
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water\_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.
Detailed description
In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.
Interventions
DRUGvitamin C
water-soluble vitamin C injection contain of 1000 mg vitamin C that given via intravenous injection
Sponsors
Shahid Beheshti University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* To be 18 years and older * No smoking * No history of bleeding disorder * No history of favism * No history of uterus, ovary, cervical cancer
Exclusion criteria
* Need to injection of vasopressor drugs * Surgeon disagreement
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| volume of hemorrhage | During surgery | volume of hemorrhage during surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hemoglobin value | 6 and 24 hours after surgery | Hemoglobin value after surgery |
| wound healing | during 2 weeks post surgery | complications after surgery |
| duration of stay in hospital | up to 2 weeks post surgery | Length of stay in hospital |
| Infection | up to 2 weeks post surgery | Developing infection up to 2 weeks |
Countries
Iran
Outcome results
None listed