Endometrial Hyperplasia, Infertility, Female, PCOS
Conditions
Brief summary
To assess the prevalence of endometrial hyperplasia (EH), endometrial intraepithelial neoplasia (EIN) and endometrial carcinoma between obese and not obese women undergoing IVF techniques for primary or secondary infertility.
Detailed description
Endometrial cancer and pre-neoplastic diseases represent the most incident gynecologic malignant pathologies found in women.1 Although diagnosed in postmenopausal patients, it can be also found in younger patients, especially when associated with some risk factors. Those include weight gain and lifestyle habits, such as consumption of fatty foods that increase estrogen levels. The positive association be- tween infertility and EC is well established. Infertile women with irregular menstrual periods, oligomenorrhea, or chronic anovulation have a risk of developing A prospective cohort study conducted at Fertility Center, OB/GYN Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy.
Interventions
PROCEDUREin-office hysteroscopy
in-office hysteroscopy with miniaturized instruments
Sponsors
University of Campania Luigi Vanvitelli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Women undergoing office hysteroscopy prior to IVF techniques
Exclusion criteria
* Severe comorbidities (i.e. cardiac, metabolic, neurologic diseases)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of endometrial hyperplasia | 12 months |
| Hormonal levels | 12 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Operator's learning curve with cumulative summation test (questionnaire) | 12 months | assess the learning curve (LC) using cumulative summation test for learning curve (LC-CUSUM). |
Countries
Italy
Outcome results
None listed