Post-mastectomy Pain Syndrome
Conditions
Keywords
Post-mastectomy Pain Syndrome, Esmolol, Perioperative
Brief summary
Chronic postoperative pain is an entity that is usually neglected by anesthetists, but several studies show that the choice of anesthetic technique may interfere with this prevalence. Esmolol is a selective beta-blocker of ultra fast duration that has been studied as a perioperative venous adjuvant with antihyperalgesic and opioid sparing action. The investigators ventured the possibility of this anti-hyperalgesic effect attenuating the chronic pain syndrome post-mastectomy.
Interventions
DRUGControl
Patients who underwent mastectomy under standard general anesthesia
DRUGEsmolol
Patients who underwent mastectomy under general anesthesia with esmolol infusion
Sponsors
Hospital de Base
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- Patients previously submitted to the study Analgesic Effect of Intraoperative Esmolol in Mastectomies: a randomized placebo controlled trial
Exclusion criteria
* Patient aged less than 18 years and over 65 years; * Patients who refuse to participate in the study; * Patients with pulmonary disease; * Patients with cardiac, renal or hepatic disease; * Use of psychoactive drug; * Patients with sinus bradycardia; * Pregnant women; * Patients with allergy to dipyrone, morphine; * Patients with chronic pain prior to the surgical procedure; * Patients with neurological disorders; * Patients undergoing surgical resurfacing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of post-mastectomy chronic pain syndrome | Through study completion, an average of 6 to 9 month | Incidence analysis using a questionnaire applied to patients in the late postoperative period. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Assess the intensity of pain: Pain Scores on the Visual Analog Scale | Through study completion, an average of 6 to 9 month | Pain Scores on the Visual Analog Scale, from zero to 10: 0 being represented by absence of pain and 10 being the worst possible pain |
| Identify possible risk factors | Through study completion, an average of 6 to 9 month | Incidence analysis using a questionnaire applied to patients in the late postoperative period. |
| Stratify the possible types of pain | Through study completion, an average of 6 to 9 month | Application of a questionnaire to identify the characteristics of pain (Neuropatic or non-neuropatic pain) |
Countries
Brazil
Contacts
Primary ContactFabricio T Mendonça, MD
Outcome results
None listed