Kidney Diseases
Conditions
Brief summary
The investigators plan a prospective cross-sectional study of pediatric and adult healthy volunteers and patients with chronic kidney disease that will correlate a variety of quantitative MRI biomarkers with severity of renal insufficiency and available histopathology. Over 3 years, the investigators will recruit approximately 20 healthy volunteers, 20 patients with chronic kidney disease (CKD) Stage 2-5, and 20 patients with renal transplant kidneys. The investigators also plan to assess the effect of inflammation on the quantitative MRI biomarkers by recruiting approximately 20 additional patients with active lupus nephritis.
Interventions
DIAGNOSTIC_TESTKidney MRI
An MRI examination will be completed per research MRI protocol.
Sponsors
Children's Hospital Medical Center, Cincinnati
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
Subjects who meet all of the following criteria will be eligible for the study: 1. ≥ 10 and ≤ 25 years of age and; 2. Kidney transplant patients, who have had a recent kidney biopsy (within 1 year) that shows interstitial fibrosis OR 3. Patients with CKD Stage 2-5 who have previously had a biopsy (within 1 year) OR 4. Lupus patients with active nephritis who will undergo biopsy evaluation before and after induction therapy OR 5. Healthy Controls
Exclusion criteria
Subjects who meet any of the following criteria will be excluded from the study: 1. Known contraindication to MR imaging (e.g., implanted non-MRI compatible device) 2. Known or suspected pregnancy. Female subjects of child bearing potential will undergo a urine pregnancy test prior to imaging. 3. Inability to undergo MRI without sedation/anesthesia. 4. Non-English Speaking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Development of noninvasive MRI methods to measure kidney disease using MR elastography. | 3 years | — |
| Development of noninvasive MRI methods to measure kidney disease using quantitative T1 mapping. | 3 years | — |
| Development of noninvasive MRI methods to measure kidney disease using T1rho mapping. | 3 years | — |
| Development of noninvasive MRI methods to measure kidney disease using T2 mapping. | 3 years | — |
| Development of noninvasive MRI methods to measure kidney disease using magnetization transfer imaging. | 3 years | — |
| Development of noninvasive MRI methods to measure kidney disease using diffusion-weighted imaging. | 3 years | Intra-voxel incoherent motion and diffusion tensor imagining will be measured. |
Countries
United States
Outcome results
None listed