Multi-slice CT Coronary Angiography in Patients With Stable Angina

Multi-slice CT Coronary Angiography Assessment of Remodeling Index in Patients With Low to Intermediate Risk Stable Angina

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03963609

Enrollment

150

Registered

2019-05-24

Start date

2016-01-01

Completion date

2018-03-01

Last updated

2019-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Stable Angina

Keywords

chronic stable angina, multislice CT, remodeling index

Brief summary

early identification of vulnerable plaques by remodeling index prior to rupture and development of acute event is of considerable importance especially by a reliable non-invasive method as CT coronary angiography.

Detailed description

single-center, cross section, observational study included 150 patients with stable angina with normal resting ECG, negative markers, normal systolic function by 2D echocardiography (EF\>50%) and without regional wall motion abnormality at rest who were referred to MSCT evaluation of the coronary artery tree.

Interventions

RADIATIONmultisclice CT

assessment of the remodeling index by multisclice CT in patients with chronic stable angina

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* first attack, low to intermediate risk stable angina * normal resting ECG, * negative markers * normal systolic function by 2D echocardiography (EF\>50%) * without regional wall motion abnormality at rest who were referred to MSCT evaluation of the coronary artery tree.

Exclusion criteria

* previous acute coronary syndrome or revascularization, those with renal impairment or dye hypersensitivity, patients with morbid obesity (BMI\>40kg/m²), rhythm other than sinus rhythm inability to hold breath for 10sec to acquire the image lesions with heavy calcium score.

Design outcomes

Primary

Measure	Time frame	Description
remodeling of the coronary artery	2 years	to study the changes in wall of the arteries in patients with chronic stable angina early changes don't appear in coronary angiography as it occurs in the form of positive remodeling which can be detected by multisclice coronary angiography Remodeling index is defined as the ratio of the maximum vessel area (or diameter) to a normal reference vessel area (or diameter), and plaques are classified as having significant positive remodeling when the remodeling index is \>1.1

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 20, 2026