Healthy Subject
Conditions
Brief summary
This trial studies glucosamine and chondroitin in preventing inflammation. Glucosamine and chondroitin often used as a dietary supplement to promote joint health may have a preventive role in inflammation and cancer. This trial may help identify the bacteria that help process them in the gut.
Interventions
DIETARY_SUPPLEMENTGlucosamine Sulfate/Chondroitin Sulfate Tablet
Given PO
OTHERPlacebo
Given PO
Sponsors
Fred Hutchinson Cancer Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
\- From the Greater Seattle area
Exclusion criteria
* Chronic medical illness, history of gastrointestinal, hepatic, or renal disorders, or inflammatory conditions (including autoimmune and inflammatory diseases) * Pregnancy or lactation * Currently on a weight-loss diet * Alcohol intake of greater than 2 drinks/day (2 drinks being equivalent to 720 ml beer, 240 ml wine or 90 ml spirits) * Current use of prescription or over-the-counter medications other than oral contraceptives and hormone secreting intrauterine device (IUD)s, multivitamin pills or infrequent use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs), or use of aspirin or NSAIDs more than 2 days per week * Abnormal renal, liver or metabolic test * Inability to swallow pills * Known allergy to shellfish * Not willing to take pills made from shellfish or animal sources * Intention to relocate out of study area within next 2 months * Any antibiotic use in the past 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants that experienced a shift in bacterial community assessed by operational taxonomic units | Up to 2 years | Shifts in the bacterial communities is based on clustering of operational taxonomic units (OTU) at 97% similarity |
Countries
United States
Outcome results
None listed