Optical Coherence Tomography and Optic Neuritis Not Related to Multiple Sclerosis

Evaluation and Follow-up of Optic Neuritis Not Related to Multiple Sclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03963310

Acronym

OCTON2

Enrollment

Registered

2019-05-24

Start date

2020-09-14

Completion date

2024-05-23

Last updated

2025-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Optic Neuritis

Brief summary

The visual prognosis of optic neuritis not related to multiple sclerosis is unknown, both in terms of functional recovery and evolution. This prospective cohort study aim to assess the ophthalmological evolution of patients presenting an episode of optic neuritis (NO) not related to a multiple sclerosis or to a clinically isolated syndrome.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* First onset of an optic neuritis lasting for less than 1 month * With a brain MRI that does not meet the MS criteria

Exclusion criteria

* Contra-indication to MRI * Pregnant or lactating woman * History of known ipsilateral optic neuritis * Ophthalmologic comorbidity in the ipsilateral eye that may interfere with the interpretation of the examinations

Design outcomes

Primary

Measure	Time frame	Description
Visual acuity (ETDRS scale)	1 year	Evolution over 1 year of the ophthalmological parameters of patients treated for an episode of optic neuritis not related to multiple sclerosis or a clinically isolated syndrome
Thickness of the layers of the retina with Optical Coherent Tomography(OCT),	1 year	—
Standard Humphrey Visual Field Test	1 year	—

Countries

France

Outcome results