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Return to Work Among Cancer Survivors With Treatment-induced Survivorship Syndromes

Return to Work Among Cancer Survivors With Treatment-induced Survivorship Syndromes

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03961217
Enrollment
2135
Registered
2019-05-23
Start date
1991-01-31
Completion date
2016-12-31
Last updated
2019-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Survivors, Gynecologic Cancer, Malignancy, Prostate Cancer, Radiation Injuries, Radiation Syndrome, Radiation Toxicity, Radiotherapy Side Effect

Keywords

Return to work, Disability pension, Sickness Absence, Employability, Fitness to work, Wellbeing, Radiotherapy Side Effect, Cancer Survivors

Brief summary

The investigators plan to investigate the consequences of late effects (radiation-induced survivorship syndromes) after radiotherapy in Gynecological and Prostate cancer survivors on return to work (Yes/No) and if RTW happened then time to RTW. In addition, whether general health, type of work (occupation), work environment factors, individual factors (lifestyle, socioeconomic status etc.), contribute to the adverse late effects of radiotherapy and these Gynecological cancer survivors have a higher risk for disability pension/long term sickness absence (NOT Return to work).

Detailed description

Occurrence of cancer diagnoses are rising, and both disease and treatments are aggressive. Due to advancement in medical technology, improved therapy and/or early detection the overall survival rates are also improving. Some of the most common cancer types, such as breast cancer, prostate cancer, cervical cancer, and colorectal cancer have high cure rates when detected early and treated according to best practices. Many of these cancer survivors are of working age and are likely to return to work. Women who survive cervical cancer and men who survive testicular cancer typically have three to four decades left in working life. However, return to work (RTW) among cancer survivors may not be similar to RTW among long-term sickness absentees due to other diagnoses. Cancer is a life threatening disease and cancer diagnose is a life changing event. The emotional shock after the cancer diagnosis may be associated with low psychological well-being even two years after prostate cancer surgery. The successful cancer treatment concludes with the lifelong consequences of surgery, irradiation, cytotoxic chemotherapy, biological anticancer substances or other drugs in the treatment. The ionizing radiation that eliminates malignant cells may trigger long-lasting pathophysiological processes in the normal tissue and affect the health of the survivors with lifelong treatment-induced survivorship diseases. In a recent study, Steineck et al, identified five radiation-induced survivorship syndromes affecting bowel health in a cohort of gynecological cancer; urgency syndrome (30%), leakage syndrome (26%), excessive gas discharge(15%), excessive mucus discharge (16%) and blood discharge (10%). There is a lack of knowledge about how these side effects of cancer treatment affect the degree of work ability and return to work. Clinical experience suggests that many cancer survivors have reduced work ability. There is a need for scientific studies that shed light on the side effects of cancer treatment and their relation to work ability.

Interventions

RADIATIONRadiotherapy

Radiotherapy as part of cancer treatment

Sponsors

Vastra Gotaland Region
CollaboratorOTHER_GOV
Sahlgrenska University Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
25 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

1. Age 25 to 60 years (working age) 2. Employed at time of diagnosis 3. Treated for cancer 4. Suffering from at least one of Radiation-induced survivorship syndromes 5. First cancer & first time treatment for cancer,

Exclusion criteria

1. No other chronic disease 2. Chronic intestinal illness/surgery 3. Stage IV cancer 4. Recurrent cancer/Relapse

Design outcomes

Primary

MeasureTime frameDescription
Return to work (RTW)Five - Ten years after mapping Radiation-induced survivorship syndromesInformation on Sickness absence for more than 14 days was obtained from the official registries in Sweden.

Secondary

MeasureTime frameDescription
Time to Return to workFive - Ten years after mapping Radiation-induced survivorship syndromesSickness absence (more than 14 days) until the survivor returned to work. Also obtained from the official registries in Sweden.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026