Conization, Fertility, High Grade Intraepithelial Neoplasia, Human Papillomavirus Infection, Precancerous Lesions, Pregnancy, Uterine Cervical Cancer
Conditions
Brief summary
This study is to investigate the oncologic and obstetric outcomes in patients with conization for uterine cervical lesions from January 1, 2000 to January 1, 2019 in Peking Union Medical College Hospital. The primary objectives consist of following: 1. The cumulative incidences of precancerous lesions and cancers of lower genital tract in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009) 2. The cumulative pregnancy rates in patients sparing the fertility The secondary objectives consist of following: 1. The effects of surgical protocols (modified Sturmdorf method and 8 figure suture) and energy equipment (cold knife and monopolar electrical cautery) on the oncologic and obstetric outcomes, and on the histological components. 2. A full description of histological components of the conization specimens 3. The cytological and virus outcomes after conization, based on the thin prep liquid-based cytology test (TCT) and high-risk human papillomavirus (HPV) testing
Interventions
DIAGNOSTIC_TESTHigh-risk HPV
High-risk HPV testing for the cytology of lower genital tract
DIAGNOSTIC_TESTTCT
Thin prep liquid-based cytology test for the cytology of lower genital tract
Sponsors
Lei Li
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Accepting conization in the study center * Aged 18 years or older
Exclusion criteria
* Not meeting any of the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The cumulative incidences of precancerous lesions or cancers | Five years | The cumulative incidences of precancerous lesions and cancers of lower genital track in patients who accepted conization for high grade intraepithelial neoplasia (HSIL), carcinoma in situ and stage IA1 cancer (FIGO 2009) |
| The cumulative pregnancy rates | Five years | The cumulative pregnancy rates in patients sparing the fertility |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The cytological results after conization | Five years | The cytological after conization based on the thin prep liquid-based cytology test (TCT) |
| The virus outcomes after conization | Five years | The virus outcomes after conization high-risk human papillomavirus (HPV) testing |
| The cumulative pregnancy loss rates | Five years | The cumulative pregnancy loss rates in patients sparing the fertility |
| The cumulative live birth rates | Five years | The cumulative live birth rates in patients sparing the fertility |
Countries
China
Contacts
Primary ContactLei Li, M.D.
Backup ContactMing Wu, M.D.
Outcome results
None listed