Delayed-onset Muscle Soreness, Muscle Soreness
Conditions
Keywords
DOMS, Fatigue rate, Heart rate variability, Pain, Jump performance
Brief summary
The study will assess the recovery and performance of young athletes suffering from muscle damage induced by physical exercise. Model by comparing the safety and efficacy of ReWin(d) supplemention during 4 weeks to placebo over 72 hours post exercice.
Detailed description
Double-blind, randomized, placebo controlled, parallel group, pilot safety and efficacy study. 40 healthy young male athetes were randomly assigned to the ReWin(d) or Placebo group. After 4 weeks supplementation (either 2 g daily of ReWin(d) capsules or placebo capsules). the participants were subjected to a 1 hour plyometric exercise session to induce DOMS. At 0 hours, 24 hours, 48 hours and 72 hours post exercise, the volunteers have been assessed to determine: (i) pain perception, (ii) fatigue rate, (iii) sport performance (effectiveness of a jump) and (iv) muscle damage and inflammation by I-R thermography and biomarkers
Interventions
DIETARY_SUPPLEMENTPolyherbal supplement: ReWin(d) vs Placebo
Supplementation during 4 weeks + 72 hours post acute exercice
Sponsors
European University of Madrid
Natural Origins
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
Single dose, Randomized, Double Blinded, Placebo-controlled Study
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* \> 18 years old * Young athletes * Training at least 3 times per week * Agree not to initiate any new exercise or diet programs during the entire study period * Agree not to change their current diet or exercise program during the entire study period * Agree not to stretch, utilize ice massage, take anti-inflammatory medications (eg, aspirin, ibuprofen), or use any other treatment for the duration of the trial.
Exclusion criteria
* Previous history of upper extremity injury or knee joint pain * Use of anti-inflammatory medications or pain medications 1 week before the screening visit and during the study * Daily use of dietary supplements and herbal supplements beginning at the screening visit and during the study * Antibiotic use in past 3 months * Chronic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of ReWin(d) on muscle recovery induced by physical exercise | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS | Sport performance (effectiveness of a jump) after exercise-induced muscle damage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of ReWin(d) on muscle damage induced by physical exercise | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session to induce DOMS | Muscle skin temperature monitored by IR-camera. |
| Effects of ReWin(d) on pain perception induced by physical exercise | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session | Visual Analogue Scale pain perception after exercise-induced muscle damage |
| Effects of ReWin(d) on fatigue rate induced by physical exercise | Change from baseline at 0 hours, 24 hours, 48 hours and 72 hours post plyometric exercises session | Heart Rate Variability assessment after exercise-induced muscle damage |
| Effects of ReWin(d) on Gut Microbiota | Change from baseline dose after 4 weeks of intervention | Determination of Microbiota composition by 16S rRNA Sequencing. |
Countries
Spain
Outcome results
None listed