Glycocalyx and Microcirculation in Sepsis

Association of Sublingual Microcirculation Parameters and Endothelial Glycocalyx Dimensions in Resuscitated Sepsis: A Cross-sectional Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03960307

Enrollment

Registered

2019-05-23

Start date

2017-07-01

Completion date

2017-09-30

Last updated

2023-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Glycocalyx, PBR, microcirculation

Brief summary

The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.

Interventions

OTHERMicrocirculation and Glycocalyx assessment

Non-invasive assessment of endothelial glycocalyx dimensions (PBR) and microcirculatory parameters (e.g. PPV, PVD, TVD, MFI)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

- septic ICU cohort: * Sepsis (based on sepsis-3 criteria) * ICU stay Inclusion Criteria - healthy controls: \- Adult healthy individuals

Exclusion criteria

(for all groups): * Underage * pregnancy * oral mucosal inflammation or injury

Design outcomes

Primary

Measure	Time frame	Description
Correlations between Perfused Boundary Region (PBR) and Microvascular Flow Index (MFI) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and MFI will be assessed in points. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and PPV will be assessed in percentage. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).
Correlations between Perfused Boundary Region (PBR) and Perfused Vessel Density (PVD) measured sublingually	During ICU stay, an average of 2 days after sepsis onset	Glycocalyx thickness will be measured with PBR (in μm) and PVD will be assessed in mm/mm\^2. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation).

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 2, 2026