Inflammatory Response, Postoperative Pain
Conditions
Brief summary
This study aims at comparing the effects of bilateral ultrasound-guided quadratus lumborum block versus lumbar epidural block on postoperative analgesia and inflammatory response following major lower abdominal cancer surgery.
Interventions
OTHERUltrasound quadratus lumborum block with bupivacaine 25%
echogenic needle will be inserted in-plane with the ultrasound beam in a posterior-to-anterior direction through the quadratus lumborum muscle until the ventral fascia of the muscle penetrated. At this point, the needle directed toward the fascial plan between the quadratus lumborum and the Psoas muscle
OTHERlumbar epideural block with bupivacaine 25%
lumbar epidural will be performed for patients in group II using a 16-gauge Touhy epidural needle by a median approach. The T12 - L1 or L1 - L2 interspaces will be chosen for the injection. The epidural space identified by the loss of resistance technique.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA II, III * Weight 50 - 85 kg. * Scheduled for major lower abdominal cancer surgery (radical cystectomy, total abdominal hysterectomy).
Exclusion criteria
* Patients with a history of relevant drug allergy. * Coagulation disorders. * Opioid dependence. * Sepsis. * Local infection at the vicinity of the block site. * Patients with psychiatric illnesses that would interfere with perception and assessment of pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pain | first 24 hours postoperatively | postoperative pain intensity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative inflammatory response | first 24 hours postoperatively | inflammatory response represented by the levels of: interleukins 1,6, and tumor necrosis factor alpha |
| side effects | first 24 hours postoperatively | sedation, nausea, vomiting, and respiratory depression |
Countries
Egypt
Contacts
Primary ContactAhmad M Abd El-Rahman, M.D.
Outcome results
None listed