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The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy in the Diagnosis of Interstitial Lung Disease

The Comparison of Uniportal and Tubeless Video Assisted Thoracic Surgery and Transbronchial Lung Cryobiopsy Within the Multidisciplinary Discussion Context in the Diagnosis of Interstitial Lung Disease

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03958162
Enrollment
60
Registered
2019-05-21
Start date
2019-06-01
Completion date
2020-06-01
Last updated
2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical Lung Biopsy, Transbronchial Lung Cryobiopsy, Interstitial Lung Disease

Keywords

surgical lung biopsy, transbronchial lung cryobiopsy, interstitial lung disease

Brief summary

To compariing the uniportal and tubeless video assisted thoracic surgery and trnsbronchial lung cryobiopsy within the multidisciplinary discussion context in the diagnosis of interstitial lung disease，and assess the safety and cost-effectiveness. This is a prospective control trial.

Interventions

DIAGNOSTIC_TESTlung biopsy

transbronchial lung cryobiopsy

Sponsors

Guangzhou Institute of Respiratory Disease
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

1. 18 yrs ≤ age\<75yrs 2. Patients diagnosed as interstitial lung disease with comprehensive clinical data (including history, serological test, spirometry test and high resolution computed tomography) 3. Further pathological data was still required after multidisciplinary discussion.

Exclusion criteria

1. Severe pulmonary dysfunction: forced vital capacity (FVC) ≤65% or carbon-monoxide diffusion coefficient (DLco) ≤45% of predicted value 2. Pulmonary hypertension: An estimated systolic pulmonary artery pressure\>50mmHg on echocardiography 3. Abnormal coagulation parameters or thrombocytopenia (\<50\*109/L) 4. Severe comorbidities leading to inoperable condition 5. Patients cannot give consent or refuse biopsy

Design outcomes

Primary

MeasureTime frameDescription
Diagnotic yieldtwo weeksPercentage of definitive diagnosis within the multidisciplinary discussion context by two different biopsy methods

Contacts

Primary ContactXiaobo Chen, Doctor
xiaobo-win@163.com+8613751721744

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026