Erythema Migrans
Conditions
Keywords
Lyme Borreliosis, Inflammation, Outcome
Brief summary
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis and to define new immune modulators that could serve as biomarkers of disease activity.
Interventions
Patient will be treated with doxycycline orally, 100 mg, bid, 7 days
DRUGDoxycycline 14 days
Patient will be treated with doxycycline orally, 100 mg, bid, 14 days
Sponsors
University of Ljubljana School of Medicine, Slovenia
University Medical Centre Ljubljana
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* erythema migrans in patients \> 18 years
Exclusion criteria
* pregnancy or immunocompromising conditions * taking antibiotic with antiborrelial activity within 10 days
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| inflammatory proteins in erythema migrans patients | up to 12 months follow-up | The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum and if available, skin, of patients during active infection and after treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| gene polymorphisms in erythema migrans patients | at enrollment | ImmunoChip single-nucleotide polymorphism array for dense genotyping of rheumtic disease-relevant genomic variants will be used. |
Countries
Slovenia
Outcome results
None listed