Arthroscopy
Conditions
Keywords
Injection, Intra-Articular, arthroscopy, ketamine
Brief summary
the aim is to compare the effects of two different doses of intraarticular ketamine on postoperative pain scores and analgesic requirements.in knee artroscopy
Detailed description
All pateints are going to be operated under general anesthesia. At the end of the study patients are going to be randomyl seperated into 3 groups. The surgeon is going the following drugs intraarticulary. Group KL1: 0.5 mg/kg ketamin in % 0..9 NaCl at a total volume of 20 ml Group KL2: 1 mg/kg ketamin in % 0.9 NaCl at a total volume of 20 ml Group SL: 20 ml % 0.9 NaCl ll patients are going to receive a periarticula injection of 10 ml 0.5 bupivacaine and patient controlled analgesia with morphine. VAS scores and total analgesic requirement is going to be evaluated.
Interventions
DRUGKetamine 1
İntrarticular Ketamine 1 mg/kg + 0.9 NaCl Total Volume 20 ml
DRUG% 0.9 NaCl
Intraarticular %0.9 NaCl
DRUGKetamine 0.5
İntrarticular Ketamine 0.5 mg/kg + 0.9 Nacl Total Volume 20 ml
Sponsors
Balikesir University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Artroscopic surgery * ASA I-II
Exclusion criteria
* Long time NSAID use * Travmatic knee injury * Long ter analgesic use * Intraartiular catheter insertion at the end of surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in postoperative pain scores throughout time evaluated by VAS | VAS scores at rest and during activity will be evaluated for 24 hours. The first measurement will be recorded immediately after surgery and at 30 minutes interval for the first hour. Afterwards at 2.4.6.12.24.hours postoperatively. | Pain scores are going to be evaluated by VAS scores at rest and VAS scores at activity |
| Difference in opioid Sparing effect measured through morphine amount delivered by a patient controlled analgesia device. | Total amount off delivered morphine will be recorded for 24 hours. | The total amount of morphine delivered by the patient controlled analgesia device in the first 24 hours will be recorded. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time for discharge measured by eligible for discharge criteria | Discharge criterias will be evaluated every three hours until postoperative 24. hour. In patients who did not complete the discharge criteria in the postoperative 24 hours period, they will be defined as prolonged discharge. | The time needed to fullfill the dicharge criteria (stable vital signs, able to walk, able to eat, nausea and vomit free, able to mixture) |
Outcome results
None listed