Low Flow Anesthesia Without Initial High Flow Phase

Comparison of Low Flow Anesthesia With and Without Initial High Flow Phase

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03955406

Enrollment

Registered

2019-05-20

Start date

2019-05-22

Completion date

2019-07-02

Last updated

2019-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low Flow Anesthesia, Volatile Anesthetic Consumption

Brief summary

The aim of the study is to compare the effectiveness of conventional low flow anesthesia (LFA) with initial high fresh gas flow ( 4L/min) for 10 minutes and LFA with fixed fresh gas flow rate (1L/min).

Interventions

PROCEDUREConventional Low flow Anesthesia

During the initial wash-in period 4 L/min Fresh gas flow will be used.

PROCEDURELow Flow Anesthesia with fixed fresh gas flow rate

Fresh gas flow rate will be 1 L/min throughout the procedure.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* ASA 1-3 * scheduled for surgery under general anesthesia with endotracheal intubation

Exclusion criteria

* hemodynamic instability * emergency cases * expected anesthesia duration \< 60 min * patient refusal

Design outcomes

Primary

Measure	Time frame	Description
The time required to reach 0.7 MAC	perioperative	—
number of adjustments made to the vaporizer settings	perioperative	MAC will be held between 0.6-0.8 with adjustments at the vaporizer

Secondary

Measure	Time frame	Description
anesthetic agent consumption	perioperative	desfluane consumption at the first hour and at the end of the surgery wil be recorded

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026