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Perioperative Fluid Management According to the Preoperative and Perioperative Glucose Level

Perioperative Fluid Management According to the Preoperative and Perioperative Glucose

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03955237
Enrollment
250
Registered
2019-05-20
Start date
2015-01-31
Completion date
2016-07-31
Last updated
2019-05-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative Complication

Brief summary

Background:Hyperglycemia and hypoglycemia both cause detrimental side effects for pediatric patients. Prolonged fasting time, age dependent physiological diffences and individual differences of patients make complicated the perioperative fluid therapy. Isotonic electrolyte solutions without glucose or with lower glucose concentrations recommended for intraoperative period in pediatric patients. Objective: The aim of this prospective study is to evaluate the different glucose concentrations(without dextrose, 1 % dextrose+LR, 2 % dextrose+LR) in perioperative infusion solutions according to preoperative blood glucose level to maintain normoglycemia in pediatric patients. Method: The consecutive 250 eligible pediatric patients aged between 6 months- 12 years with ASA risk score of I-II undergoing surgery lasting less than four hours were enrolled the study in six months period. Patient demographics, procedure, preoperative fasting time, preoperative and postoperative glucose levels were documented. Lactate ringer (LR) solution with % 2 glucose was infused to the patients with preoperative blood glucose level lower than 60 mg/dL, LR solution with % 1 glucose was used for the patients with preoperative blood glucose level between 60-90 mg/dL, LR solution without glucose was used for the patients with preoperative blood glucose level higher than 90 mg/dL.

Detailed description

Lactate ringer (LR) solution with % 2 glucose was infused to the patients with preoperative blood glucose level lower than 60 mg/dL, LR solution with % 1 glucose was used for the patients with preoperative blood glucose level between 60-90 mg/dL, LR solution without glucose was used for the patients with preoperative blood glucose level higher than 90 mg/dL

Interventions

PROCEDUREDrug: dextrose containing infusion

Drug: infusing dextrose containing or non glucose fluid according to blood glucose level

Sponsors

Istanbul University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

3 different type of fluid

Eligibility

Sex/Gender
ALL
Age
6 Months to 12 Years
Healthy volunteers
No

Inclusion criteria

; * 6 months- 12 years old, ASA I-II children * Undergoing surgery lasting less than four hours were enrolled the study

Exclusion criteria

* Diabetes mellitus * Parenteral nutrition or enteral nutrition * Patient with metabolic disorders, * ASA III-IV patients

Design outcomes

Primary

MeasureTime frameDescription
glucose levelperioperative periodblood glucose level measurement with finger stick monitoring

Secondary

MeasureTime frameDescription
hyperglysemia or hypoglysemia ratioperioperativeblood glucose level measurement with finger stick monitoring

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026