Alzheimer Disease, Cognitive Change
Conditions
Keywords
Alzheimer Disease, Cognitive Exercises, Internet, Donepezil, Memantin, Combination
Brief summary
In this study, it is aimed to compare the effects of cognitive exercises applied on long-term internet environment to the cognitive level of patients who received donepezil, memantine or donepezil / memantin combination therapy.
Interventions
COMBINATION_PRODUCTEbicomb
Combination product and combination product plus cognitive exercises will primarily be evaluated in this study
Sponsors
Neutec Ar-Ge San ve Tic A.Ş
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
55 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients between 55-90 years old who were diagnosed with Alzheimer's Dementia and had no history of cerebrovascular disease during the last 6 months, * Patients without other neurodegenerative diseases and secondary dementia diagnoses, * Patients with MOCA score of between 13-18, * Patients with at least primary school graduation, * Patients who have had no CNS disease including trauma in the last year, * Patients without a diagnosis of psychiatric disease, * Patients with a tablet or PC with an internet connection, * Patients agreeing to perform BEYNEX daily activity at least 5 times per week, * Patients signing informed consent form.
Exclusion criteria
* Patients who have hypersensitivity to study working drugs, * Psychotic patients, * Disabled patients with orthopedic dominant extremity, * Patients with ICU follow-up due to trauma in the last 6 months, * Patients with severe visual impairment or eye surgery, * Patients who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in MOCA total score | 6-months | MOCA: Montreal - Cognitive Assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in clock drawing test | 6-months | The subject is asked to draw the face of a clock with all numbers and to set the hands for a specified time (hh:mm) and will be evaluated according to ability to draw. |
| Change in GDS total score | 6-months | GDS (The Geriatric Depression Scale) |
| Change in ADAS-Cog total score | 6-months | ADAS-Cog: Alzheimer's Disease Assessment Scale- Cognitive Subscale |
| Change in CDR total score | 6-months | CDR: The Clinical Dementia Rating |
| Change in B-ADL total score | 6-months | B-ADL: The Bayer Activities of Daily Living Scale |
Countries
Turkey (Türkiye)
Contacts
Primary ContactNeutec RD
Outcome results
None listed