Perioperative Antihypertensive
Conditions
Brief summary
A cohort of hypertension patients undergoing elective non-cardiac surgery was constructed to investigate current status of antihypertensive drug treatment in non-cardiac surgical population.
Detailed description
Perioperative changes in blood pressure (BP) are associated with perioperative risks. However, there is little information regarding the current status of antihypertensive treatment in non-cardiac surgical population. A cohort of 351 hypertension patients aged between 18 to 85-year old undergoing elective non-cardiac surgery was constructed to investigate the application of antihypertensive drugs, systemic involvement, perioperative hemodynamics and internal environment to grasp the perioperative impact of different antihypertensive drugs, and to further provide a reference for the preoperative antihypertensive strategy of surgery patients.
Interventions
None listed
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing elective non-cardiac surgery with hypertension(i.e., with a systolic blood pressure(SBP) of \>=140 mmHg and/or a diastolic blood pressure(DBP) of \>=90 mmHg based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) or self-reported use of antihypertensive medication
Exclusion criteria
* Patients under the age of 18 years old * Patients more than 85 years old * Patients suspected of intracranial hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| perioperative blood press(BP) | from the moment on arrival to the operating room until the moment leaving PACU, assessed up to 240 minutes. | baseline BP before the operation, when entering and exiting post-anesthesia care unit(PACU) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pH, base excess, and concentration of HCO3- in blood gases | 5 minutes after extubating in PACU | arterial blood gases detected by using the ABL800 (Radiometer Med Aps Ltd, Copenhagen, Denmark) |
| the incidence of hypotension in PACU | from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes. | If there were more than two consecutive episodes of hypotension (which was defined as SBP less than 80% of baseline) a rescue intravenous bolus of 100 mg of phenylephrine was given. |
| the incidence of hypertension in PACU | from the moment on arrival to PACU until 60 minutes after arriving or the moment leaving PACU, whichever came first, assessed up to 240 minutes. | the incidence of hypertension, which was defined as SBP greater than 120% of baseline |
| hospitalization days | from the date of admission until the date of discharge or date of death from any cause, whichever came first, assessed up to 100 days | The duration of this single episode of hospitalization |
Countries
China
Outcome results
None listed