Indications for Care in Pregnancy; Labor; and Delivery
Conditions
Keywords
melatonin,colostral milk,IL-6, delivery, cesarean section
Brief summary
The comparison of serum and colostral melatonin, and IL-6 levels between women with vaginal delivery, emergency cesarean section and elective cesarean section
Detailed description
In this prospective randomized study, the investigators aimed to show the changes in the melatonin levels in colostral milk in spontaneous vaginal delivery,emergency cesarean and elective cesarean section patients and changes in blood IL-6 level before and after the delivery in same patient groups. the investigators randomized 30 cases for each group for comparisons.Time range seems short in this study but participating hospital setting is a busy maternity hospital thus it will be performed easily. The purpose of this study is to demonstrate the beneficial effect of spontaneous vaginal delivery on the secretion of melatonin which is solely secreted by the mother and the newborn is dependent on maternal milk oriented melatonin until 12 th week after delivery
Interventions
OTHERThe calculation of blood IL-6 and coloctral milk melatonin
Collected maternal colostral milk will be sampled for melatonin levels.Blood samples driven before and after delivery will be evaluated for IL-6 levels in each group
Sponsors
Samsun Education and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women reached term * Patients with spontaneous vaginal delivery * Patients preferred cesarean section electively * Patient who had emergency cesarean section without additional medical or surgical problems
Exclusion criteria
* Women who had history of intrauterine fetal loss * Hypertention during pregnancy * Anemia * Thyroid diseases * Patients with chronic diseases * Smokers * Drug users
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The serum IL-6 level | 8 weeks | the measurement of serum IL-6 level in blood |
| Colostral Milk melatonin levels in different types of deliveries | 8 weeks | Colostral milk taken from the postpartum midnight breast milk were evaluated for melatonin levels |
Countries
Turkey (Türkiye)
Outcome results
None listed