Thalassemia Major
Conditions
Brief summary
Patient with thalassemia major have many endocrine diseases, such as hypopituitarism, hypothyroidism, hypoparathyroidis, osteoporosis, and etc.. These problems may be due to anemia itself or related to iron deposition. This study aimed to investigate the endocrine aspect of thalassemia major patients in Taiwan in order to introduce early intervention or treatment in the future.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Thalassemia major * Patients of 20-85 years old
Exclusion criteria
* Patients younger than 20 years old. * Patients older than 85 years old. * Patients who are pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Abnormal bone mineral density rate | 10 years | abnormal bone mineral density is defined as T-score \< -1 SD in menopause women or men older than 50 years old, or Z score \< -2 SD in premenopausal women or men not older than 50 year old. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| abnormal thyroid function rate | 10 years | abnormal thyroid function is defined as abnormal free thyroxine or abnormal thyrotropin. Normal range of free thyroxine is 0.6-1.75 ng/dl. normal range of thyrotropin is 0.1-4.5 mU/l. |
| abnormal pituitary function rate | 10 years | abnormal pituitary function is defined as any of the abnormality in serum adrenocorticotropin (pg/l), IGF-1 (ng/ml). thyrotropin (mU/l), FSH (U/l), LH (U/l) |
Countries
Taiwan
Contacts
Primary ContactShyang-Rong Shih, MD, PhD
Outcome results
None listed