Diagnostic Utility of Exercise Cardiac Magnetic Resonance in the Assessment of Cardiac Dyspnea.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03951779

Enrollment

Registered

2019-05-15

Start date

2018-12-14

Completion date

2020-01-10

Last updated

2022-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac; Dyspnea, Shortness of Breath

Brief summary

Researchers are examining the diagnostic utility of an exercise cardiac MRI (eCMR) in the assessment of cardiac dyspnea (shortness of breath).

Interventions

DIAGNOSTIC_TESTExercise cardiac magnetic resonance imaging

Subjects will exercise on a treadmill and immediately following the completion of the stress protocol, subjects will undergo cardiac magnetic resonance imaging

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Consecutive patients aged ≥18 years years with suspected cardiac dyspnea who are scheduled to undergo right heart catheterization as dictated by a comprehensive examination and echocardiography will be included for enrollment.

Exclusion criteria

* Age \<18 years * Pregnancy * Mechanical ventilation * Acute or chronic renal failure (creatinine clearance \<30 ml/min or requiring renal replacement therapy) * Inability to perform MRI (i.e. claustrophobia, severe obesity (\>150 kg), device incompatible with MRI) * Inability to exercise * Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths) * Prior heart or lung transplantation * Left ventricular systolic (ejection fraction \<50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction) * Significant left-sided valvular disease (≥moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery

Design outcomes

Primary

Measure	Time frame	Description
Ejection Fraction	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMR) reported in percentages
Stroke Volume	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in mL
Longitudinal Strain Assessment	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in percentages

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026