Non Small Cell Lung Cancer
Conditions
Brief summary
Retrospective analysis where patients with histologically confirmed Non-small cell lung cancer (NSCLC) were centrally evaluated for the presence of KRAS and EGFR mutations.
Detailed description
A retrospective analysis, performed by the Hellenic Co-operative Oncology Group (HeCOG), in samples from patients with histologically confirmed NSCLC, who had been treated within HeCOG-affiliated centres from March 2000 through December 2012, were centrally evaluated for the presence of KRAS and EGFR mutations. All patients had available clinicopathological data at diagnosis. Formalin-fixed, paraffin-embedded tissue blocks were retrospectively retrieved from the HeCOG tumor repository. Cytologic material was prospectively submitted for genotyping in more recent years (2010-2012).
Interventions
None listed
Sponsors
Hellenic Cooperative Oncology Group
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with histologically confirmed NSCLC * Signed and dated written informed consent * Age 18 years * Available cytological material
Exclusion criteria
-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival | from the date of treatment start until verified disease progression, death from any cause or date of last contact whichever occurred first, up to 9 months |
| Overall survival | from the date of treatment start until verified disease progression, death from any cause or date of last contact whichever occurred first, up to 36 months |
Countries
Greece
Outcome results
None listed