Dynamic Changes of Gut Microbiota in UC After FMT

Dynamic Changes of Gut Microbiota in Patients With Ulcerative Colitis After Fecal Transplantation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03949257

Enrollment

Registered

2019-05-14

Start date

2019-06-01

Completion date

2019-12-01

Last updated

2019-05-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative Colitis

Keywords

transendoscopic enteral tubing, gut microbiota, ulcerative colitis

Brief summary

A prospective study to investigate the dynamic changes of gut microbiota through colonic transendoscopic enteral tubing in patients with ulcerative colitis after fecal microbiota transplantation.

Detailed description

Colonic transendoscopic enteral tubing (TET) is a novel, safe, convenient, and reliable way for fecal microbiota transplantation (FMT) and the whole-colon enema treatment. This tube also can serve as a medium for collecting gut microbiota. Fecal Microbiota Transplantation (FMT) was identified to be promising for ulcerative colitis (UC). This study aims to investigate the dynamic changes of gut microbiota in patients with UC after FMT.

Interventions

DEVICEcolonic transendoscopic enteral tubing

Colonic transendoscopic enteral tubing (TET) is a novel, safe, convenient, and reliable way for fecal microbiota transplantation (FMT) and the whole-colon enema treatment.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

7 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients were diagnosed with mild or moderate ulcerative colitis. * Patients need colonic TET and FMT * Must be able to colonic TET and no contraindication by endoscopic examination, consent colon TET implantation and not associated with severe intestinal lesions such as fistula, stenosis, complex perianal lesions, severe ileocecal or ascending colon lesions resulting in no proper site for titanium clip fixation. * Age \> 7 years old and \< 65 years old

Exclusion criteria

* gut microbiota was not collected successfully

Design outcomes

Primary

Measure	Time frame	Description
changes of gut microbiota	7 days	gut microbiota will be collected through the colonic TET

Secondary

Measure	Time frame	Description
frequency of defecation	7 days	the frequency of defecation in UC patients will be recorded

Countries

China

Contacts

Primary Contactfaming zhang, MD; PhD

fzhang@njmu.edu.cn086-25-58509883

Backup Contactmin dai, MD; PhD

daimin@njmu.edu.cn086-25-58509884

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026