Tobacco Use Disorder
Conditions
Brief summary
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT). MORE is a behavioral therapy that integrates mindfulness training to modify reward processes. CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Interventions
MORE is a behavioral therapy that integrates mindfulness training to modify reward processes.
BEHAVIORALCognitive Behavioral Therapy (CBT)
CBT is a therapy designed to help individuals understand how their thoughts and feelings influence their behaviors.
Sponsors
Medical University of South Carolina
University of Missouri-Columbia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age 18 and up * English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks * Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks * Current nicotine dependent smoker with a minimum smoking history of 2 years * Interest in quitting smoking
Exclusion criteria
* Use of psychotropic (e.g. antiepileptic) medications in the past month * Positive urine drug screen * Presence of an untreated medical illness * Current or past psychosis * History of major neurological illness or head injury resulting in loss of consciousness * And contraindication to MRI, including claustrophobia * Among females, positive urine pregnancy test * Inability or unwillingness of subject to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cigarette Smoking | 7 weeks | Biochemical smoking assessment (breath carbon monoxide) at each study visit. |
| Magnitude of change in fMRI brain response to images | 7 weeks | Measure the effects of MORE on fMRI BOLD response to images (change from baseline to end of study) while participants undergo functional magnetic resonance imaging |
| Magnitude of change in fMRI brain connectivity | 7 weeks | Measure the effects of MORE on resting-state functional connectivity (change from baseline to end of study) while participants undergo functional magnetic resonance imaging. |
Countries
United States
Contacts
Primary ContactMadhura Athreya, MS
Backup ContactBrett Froeliger, PhD
Outcome results
None listed