Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03948425

Acronym

AVC_AIGUS

Enrollment

Registered

2019-05-14

Start date

2017-06-08

Completion date

2019-07-31

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke, Acute

Brief summary

* Generate a dynamic mapping of the distribution of iodine within the cerebral parenchyma in the patient suspected of acute ischemic disorder with the CT spectral scanner. * Correlate the anomalies of iodine mapping to the other parameters acquired during the classic dynamic infusion phase to define the ischemic area (MTT higher and rCBV normal) versus infarcted zone (MTT higher and rCBV decreased)

Interventions

RADIATIONspectral CT

Head spectral CT

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to 95 Years

Healthy volunteers

Inclusion criteria

* Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms) * Age between 50 and 95 years * Weight: between 65 and 95 kg

Exclusion criteria

* Documented or suspected allergy to IV iodinated contrast media * Renal impairment with creatinine clearance \<60 ml / min * Hemorrhagic lesions or vascular abnormalities demonstrated on CT before contrast injection

Design outcomes

Primary

Measure	Time frame	Description
Cerebral Blood Volume (CBV)	from start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)	CBV is measured in units of milliliters of blood per 100 g of brain and is defined as the volume of flowing blood for a given volume of brain.
Mean Transit Time (MTT)	rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)	MTT is measured in seconds and defined as the average amount of time it takes blood to transit through the given volume of brain.
Cerebral Blood Flow (CBF)	rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)	CBF is measured in units of milliliters of blood per 100 g of brain tissue per minute and is defined as the volume of flowing blood moving through a given volume of brain in a specific amount of time.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026