Ginseng HRG80 in Stress and Fatigue

Study of the Efficacy of Panax Ginseng Herbal Preparation HRG80 for Prevention and Mitigation of the Symptoms of Stress in Healthy Subjects

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03947554

Enrollment

Registered

2019-05-13

Start date

2019-04-01

Completion date

2019-07-01

Last updated

2019-07-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychological Stress

Keywords

Panax ginseng, Red ginseng, Korean ginseng, Adaptogen

Brief summary

This study evaluates the effects of a specific herbal preparation of Panax ginseng in preventing symptoms of stress in healthy individuals.

Detailed description

HRG80 is an herbal preparation of Panax ginseng with a higher concentration of bioavailable ginsenosides than typical Korean ginseng. This study will test whether HRG80 is effective at preventing symptoms of stress, such as fatigue, impaired memory, difficulty in concentration, attention deficit, restlessness, and irritation related to daily work situations of healthy individuals in comparison to placebo and a standard Pananx ginseng with a lower concentration of ginsenosides.

Interventions

DIETARY_SUPPLEMENTHRG80 Panax ginseng

Panax ginseng containing 63.4 mg ginsenosides

DIETARY_SUPPLEMENTPanax ginseng

Panax ginseng containing 19.6 mg ginsenosides

DIETARY_SUPPLEMENTPlacebo

800 mg excipient

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Individuals experiencing at least one symptom of stress and fatigue during 8 hours of mental work with a computer. * Men and women ages 18-65 (all races and ethnicities) * Able to understand and participate in an 11-week study

Exclusion criteria

* Taking medicine or dietary supplements which may have potential effects on cognitive function * Consuming more than 1 cup of coffee daily (in the morning).

Design outcomes

Primary

Measure	Time frame	Description
Change in Perceived Stress Scale (PSS) from baseline to the last day of treatment	Two weeks	The Perceived Stress Scale is a psychological instrument for measuring the perception of stress by an individual. Scores from 0-13 indicate low stress, 14-26 is considered moderate stress, and scores from 27-40 indicate high perceived stress. The primary outcome is the change in the baseline PSS score for HRG80 versus standard Panax ginseng and placebo.

Countries

Armenia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026