Neuroblastoma Survivors
Conditions
Keywords
Kidney Function, Biomarkers, 19-160
Brief summary
The main purpose of this study is to learn more about biomarkers of kidney function in the blood and urine of neuroblastoma survivors. A biomarker is a biological molecule found in blood, urine, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition.
Interventions
OTHERUrine sample
The urine collected from the first morning void will be used to assess urine creatinine and microalbumin. The fresh urine specimen will be analyzed for novel urinary biomarkers of (urinary NGAL, TGF-β1, IL-18 and KIM-1). Serum BUN, creatinine, and cystatin-C will be assessed using serum samples drawn for routine clinical care.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 20 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of neuroblastoma between 0-18 years of age * \< 21 years of age at time of study enrollment * Two or more years from completion of systemic chemotherapy and/or radiation therapy
Exclusion criteria
* Patients treated with observation only * Patients with multiple primary cancers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| indicators of renal injury | 2 years | urine collected from the first morning void will be used to assess urine creatinine |
Countries
United States
Outcome results
None listed