Heart Diseases, Cardiac Conduction Defect
Conditions
Keywords
Electrocardiography, Body Surface Potential Mapping, Computational Biology
Brief summary
Non-invasive reconstruction of electrical heart activity can yield important scientific and clinical insights in cardiac rhythm disorders. In this study, The investigators aim at developing methods for reconstructing electrical heart activity non-invasively, and to use these methods to investigate cardiac rhythm disorders to answer clinical and scientific questions.
Interventions
RADIATIONComputed tomography (CT) scan
A CT scan of thorax and heart will be performed in the CT+BSPM group.
DEVICEBody-surface potential mapping
Measurement of 256-lead body-surface electrocardiogram
Sponsors
Maastricht University Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Overall Inclusion Criteria: * 18 years or older * able to provide informed consent * Conditions that might alter electrical conduction properties in the heart, including (but not limited to): Brugada syndrome (BS), Arrhythmogenic right ventricular cardiomyopathy (ARVC), demonstrated ventricular arrhythmias (resuscitation, (non)sustained ventricular tachycardia, ventricular fibrillation) * Implanted cardiac device, such as pacemaker or implantable cardioverter defibrillator Additional Inclusion Criteria for group 1 (CT group): \- Existing medical indication for a cardiac CT scan unrelated to this research There are no additional inclusion criteria for group 2 (no-CT group).
Exclusion criteria
\- Known strong reaction against electrode attachment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epicardial potentials | Day one, direct measurement | Primary outcome data include reconstructed electrical heart activity such as: \- epicardial potentials (units: millivolts \[mV\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: \- Reconstructed epicardial potentials (mV) will be compared to selected invasive epicardial potentials (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data |
| Epicardial electrograms | Day one, direct measurement | Primary outcome data include reconstructed electrical heart activity such as: \- epicardial electrograms (units: millivolts \[mV\] over milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: \- Reconstructed electrograms (mV) will be compared to selected invasive epicardial electrograms (mV) obtained from catheter-based recordings or pacemaker-based recordings available as clinical data |
| Epicardial activation and recovery sequences | Day one, direct measurement | Primary outcome data include reconstructed electrical heart activity such as: \- epicardial activation and recovery isochrones (units: milliseconds \[ms\]) These outcome data are obtained at the moment of inclusion. The primary outcome measures are a comparison of the primary outcome data with invasive outcome data available from clinical records: \- Reconstructed activation and recovery sequences (ms) will be compared to recorded catheter-based sequences from clinical data (ms). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Disease-specific differences in primary outcome measures | Day one, direct measurement | The secondary study endpoints include disease-specific differences of the primary outcome measures, which may include abnormal (low-amplitude, fractionated) electrograms and abnormal activation and recovery sequences. Depending on the primary measure, these differences will be expressed in absolute units (mV, ms) or relative differences (%). |
Countries
Netherlands
Outcome results
None listed