Cardiorespiratory Responses to Treadmill Running at Different Slopes

Comparison of Cardiorespiratory Responses to Treadmill Running at Different Slopes in Well-trained Athletes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03946215

Enrollment

Registered

2019-05-10

Start date

2018-09-01

Completion date

2018-12-17

Last updated

2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiorespiratory Responses, Well-trained Athletes

Brief summary

The purpose of this study is: i) to determine if maximal oxygen uptake in downhill running is significantly different versus flat or uphill running, and ii) to compare cardiorespiratory and muscle fatigue responses to uphill vs flat and downhill running at similar running velocity and similar metabolic power. The investigators hypothesized that maximal oxygen uptake will be lower in downhill running. The investigators also anticipate attenuated cardiorespiratory and muscle fatigue responses to downhill running when compared to flat or uphill running performed at similar velocity but not when the comparison is done at similar metabolic power.

Interventions

OTHEREach participant will perform:

Part 1: Maximal incremental tests will require running at fixed slopes (+15%, 0% -15%) for stages (2min duration) of increasing velocities (0.5, 1 and 1.5 km/h) Part two: submaximal running tests will require running at constant velocity (80% VO2max uphill; 80%VO2max downhill and downhill at similar velocity as uphill)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* to be a well-trained runner with a VO2max \> à 55 ml/kg/min * nonsmoker or stopped smoking for 5 years * BMI \< 25 * affiliation to the social health insurance scheme * signing an informed consent form.

Exclusion criteria

* impossibility to give the subject enlightened information (subject in emergency situation, difficulties in understanding the study, ...); * subject under the protection of justice * subject under guardianship or curatorship * contraindication to the practice of physical and sport activities * lower limbs musculotendinous or articular problems * respiratory, cardiovascular or metabolic pathology * drug treatment in progress and impossibility to stop it within 7 days before the beginning of the study

Design outcomes

Primary

Measure	Time frame	Description
Peak oxygen	15 minutes	The peak oxygen uptake will be collected during downhill, flat and uphill running

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026