Influence of Hyperbilirubinaemia on Two Different Near Infrared Spectroscopy Devices

Influence of Hyperbilirubinaemia on Foresight and INVOS Oximetry Values in Pediatric Hepatic Transplantation

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03945942

Acronym

NIRS_GREFFE

Enrollment

Registered

2019-05-10

Start date

2019-03-15

Completion date

2020-10-15

Last updated

2021-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Transplant; Complications

Brief summary

Protocol Near infrared spectroscopy liver transplants: comparison of two monitoring of Near infrared spectroscopy in pediatric liver transplant.

Detailed description

Hyperbilirubinaemia may interfere with oximetry values as measured by Near Infrared Spectroscopy devices. The number of wave lengths used by different devices can influence the oximetry values in adult patients. This has never been demonstrated in children with hyperbilirubinaemia scheduled for elective liver transplantation.The study will compare cerebral and somatic oximetry values measured by two different Near infrared spectroscopy devices (FORESIGHT and INVOS) and analyse the influence of bilirubin levels on these differences.

Interventions

DEVICENear infrared spectroscopy with INVOS device

somatic and cerebral oximetry by INVOS in pediatric liver transplantation

DEVICENear infrared spectroscopy with Foresight device

somatic and cerebral oximetry with Foresight device in pediatric liver transplantation

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Inclusion criteria

* Pediatric patients 0 to 18 years, with a liver transplant with living donor program of our institution * Free, informed and written consent signed by the investigator or employees and by the legal guardians of minor patients in the days preceding the procedure

Exclusion criteria

* refusal of the patient or his parents to consent * known brain or Neurological pathology

Design outcomes

Primary

Measure	Time frame	Description
influence of chromophores such as bilirubin on oximetry values provided by two different devices	From Day 0 of surgery until arrival at pediatric intensive care unit (up to 12 hours)	measure of oximetry values by two different devices at different time points in function of serum bilirubin levels

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026