Iron Deficiency Anemia
Conditions
Keywords
iron deficiency anemia (IDA), iron status, mother-infant interactions, intervention study, postpartum depressive symptoms
Brief summary
This study aims to examine the relation between iron status and maternal-child interactions as well as maternal depressive symptoms in mothers from central Pennsylvania.
Detailed description
Investigators aim to follow mothers and their infants from 6 weeks to 6 months in the postpartum to understand the relation between iron status and mother-child interactions and depressive symptoms. During this period, iron deficient anemic mothers will receive an intervention with iron with the scope of improving iron status, reducing their depressive symptoms, and in turn, increasing the quality of parenting behaviors during mother-child interactions. The control group will be iron sufficient mothers who will receive a placebo.
Interventions
DIETARY_SUPPLEMENTIron
65 mg of iron (ferrous sulfate)
DIETARY_SUPPLEMENTGelatin
600 mg gelatin
Sponsors
Penn State University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
A study staff not involved with data analyses or outcome assessment will provide the intervention to participants.
Intervention model description
Iron deficient anemic (IDA) mothers will be given an iron supplement versus iron sufficient (control; CN) mothers will be given a placebo (gelatin pill) daily.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Pregnant women between 18 - 40 years. 2. Mother expects to be the primary caregiver for the infant for study duration and will allow infant to be enrolled in the study.. 3. Mother has no history of gastrointestinal or hematological disorders and not taking medications that interfere with hematopoiesis or absorption. 4. After birth, the mother and baby are healthy, delivery was of one infant only, infant gestational age ≥ 38 weeks, infant weight ≥ 2500 g (5.5 lbs), neither the mom nor the infant received a blood transfusion at or since delivery, and mom agrees to discontinue use of any iron containing medications.
Exclusion criteria
1. Maternal age ≤ 18 and \> 40 years 2. Evidence of a history of gastrointestinal or hematological disorders and evidence of taking medications that interfere with hematopoiesis or absorption. 3. Severely anemic (Hemoglobin \< 90 g/L) 4. Iron deficient but not anemic women 5. Non-English speaking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mother-child interaction scores in the postpartum period | 1 year | Mother child-interactions will be measured via the Emotional Availability Scales and microanalytic coding. Scores will be compared between iron deficient and iron sufficient women. Investigators will also examine change in scores within group from baseline to endline. The Emotional Availability Scales consist of 6 subscales, 4 for the mother and 2 for the child. Maternal subscales include sensitivity, structuring, non-intrusiveness, and non-hostility; child subscales include involvement and responsiveness. All are scored on a scale of 1 - 7 with higher scores indicating a more optimal score. |
Outcome results
None listed