Tooth Extraction, Dental Implants
Conditions
Keywords
Tooth extraction, Socket regeneration, Dental Implants
Brief summary
The purpose of this study is to compare the clinical success, radiographical volume maintenance and histological bone regeneration after using either a bovine bone xenograft or an autogenous platelet rich plasma enrich in growth factors, known as Endoret®-PRGF®.
Interventions
DEVICEPRGF
After tooth extraction, the socket will be grafted with PRGF-Endoret
DEVICEABB
After tooth extraction, the socket will be grafted with Geistlich Bio-Oss® Collagen
Sponsors
BTI Biotechnology Institute
Universidad de Granada
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Upper or lower premolar or molar tooth in need of extraction and later restoration by dental implant. * Adjacent and opposing natural teeth present and healthy. * At least 3 mm from the tip of the dental root to the maxillary sinus or the inferior alveolar canal.
Exclusion criteria
* Active local infection. * Uncontrolled diabetes mellitus. * Long term (\>10 years) use of oral bisphosphonates. * Use of intravenous bisphosphonates. * Recent use (\<3 months) of antibiotics, antiinflammatories or analgesics drugs. * Pregnancy. * Smokers of more than 10 cigarettes per day. * Any oral pathology that needs to be treated before tooth extraction, particularly the presence of more than 25% of sites with bleeding on probing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Alveolar bone change in Cone Beam Computerized Tomography | Baseline and 4 months | Volumetric change in the alveolar bone from immediately after tooth extraction to immediately before implant placement (4 months after the extraction and grafting of the socket) |
Countries
Spain
Outcome results
None listed