Comparison of Lysine Clonixinate, Ketorolac and Metamizole Sodium in Scorpion Stings

Randomized Clinical Trial: Comparison of Lysine Clonixinate, Ketorolac and Metamizole Sodium in Poisoning by Scorpion Stings

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03943199

Enrollment

160

Registered

2019-05-09

Start date

2019-05-05

Completion date

2019-07-20

Last updated

2019-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesic, Pain, Scorpion Stings

Brief summary

The cases of scorpion stings are matters of medical importance, where Mexico is considered as one of the main countries of such public health problem.

Detailed description

The states with the highest incidence of cases in 2018 were Jalisco with 47370 bite reports, Guerrero with 40672 cases and Guanajuato with 40331, according to the national epidemiological surveillance system. Due to the high affinity on ion channels, where a cystine inhibitor BmP01, it is directed to the nociceptive ion channel TRPV1 to produce pain.Pain has been reported to occur in approximately 97% of patients They are seen in the emergency room.

Interventions

DIAGNOSTIC_TESTVisual Analogue Scale for pain

Will be assessed at 0´, 30´, 60´, 90 minutes and 18 hours after the application of the analgesic.

Study design

Allocation

RANDOMIZED

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of pain by scorpion stings * Patients\> 18 years old * Clinical diagnosis of scorpion sting poisoning grade I, II and III. * Chronic degenerative diseases (renal failure, hypertension, liver damage)

Exclusion criteria

* Patients who reject the continuation of medical treatment * Patients who are transferred to a unit of second level of care. * Patients with pharmacological treatment prior

Design outcomes

Primary

Measure	Time frame	Description
Evaluate the efficacy of antivenom as a pain treatment by the visual analogue scale of pain in poisoning by scorpion stings.	18 hours after drugs in study	Comparison of venom metabolism in patients valued at 18 hours with Visual Analog Scales (VAS) valued from 0 to 10

Secondary

Measure	Time frame	Description
Evaluate the analgesic efficacy of clonixinate of lysine, ketorolac and sodium metamizol, by the visual analogue scale of pain in poisoning by scorpion stings.	0, 30, 60 and 90 minutes after administered the drug	Comparison of the effectiveness inter group over the pain by scorpion sting by Visual Analog Scales (VAS) valued from 0 to 10

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026