Laparoscopic Adrenalectomy, Nerve Block, Pain Management
Conditions
Keywords
transmuscular quadratus lumborum block, adrenalectomy
Brief summary
This prospective, randomized control study aims to compare the analgesic effect, satisfaction with anesthesia and analgesia between single-injection QLB (quadratus lumborum block)+general anesthesia (GA) and general anesthesia (GA) alone in patients undergoing laparoscopic adrenalectomy.
Interventions
Inject 0.4ml/kg 0.5% ropivacaine between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose ropivacaine 0.4ml/kg 0.5% ropivacaine is given immediately after the correct position of needle tip is verified.
PROCEDUREPlacebo Control
Inject 0.4ml/kg saline between quadratus lumborum and psoas major muscle Device: The curved (C1-5) probe of Ultrasound Scanner Philips CX50 is used for scan Drug: single dose 0.4ml/kg 0.9% NS is given immediately after the correct position of the needle tip is verified
Sponsors
Peking Union Medical College Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-70 yrs * American Society of Anesthesiologists physical statusⅠ-Ⅲ * Undergo laparoscopic adrenalectomy * Informed consent
Exclusion criteria
* a known allergy to the medications being used for anesthesia * coagulopathy or on anticoagulants * chronic opioid therapy or history of substance abuse * participating in another RCT * inability to properly describe postoperative pain to investigators (e.g., language barrier, neuropsychiatric disorder).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the NRS pain scores on activity 12-hours after surgery | 12-hours after surgery | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of postoperative nausea and vomiting (PONV) | within 24 postoperative hours | — |
| ambulation time | within 5 days after surgery | — |
| time of recovery of bowel movement | within 5 days after surgery | defined as the time to first flatus |
| the pain scores at rest determined by the numeric rating scale (NRS, 0-10) | At 2,4, 8, 12, 24 ,48,72 hours after the surgery | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool |
| patient's satisfaction of anesthesia and analgesia | 48 hours after surgery | use the Chinese version of Bauer questionnaire to assess the patient satisfaction of anesthesia |
| the NRS pain scores on activity after surgery | At 2,4, 8, 24 ,48,72 hours after the surgery | The NRS (a number scale from 0 to 10) is a commonly used pain intensity rating tool |
| postoperative length of hospital stay | up to 2 weeks after surgery | — |
Countries
China
Outcome results
None listed