Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03941184

Enrollment

114

Registered

2019-05-07

Start date

1995-01-01

Completion date

2020-11-10

Last updated

2020-11-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome, Celiac Disease, Crohn Disease, Dermatomyositis, Graves Disease, Guillain-Barre Syndrome, Hashimoto Thyroiditis, Hepatitis, Autoimmune, Multiple Sclerosis, Myasthenia Gravis, Pernicious Anemia, Polymyalgia Rheumatica, Polymyositis, Primary Biliary Cirrhosis, Psoriasis, Raynaud, Rheumatoid Arthritis, SCAD, Sjögren Syndrome, Systemic Lupus Erythematosus, Systemic Sclerosis, Takayasu Arteritis, Type 1 Diabetes Mellitus, Ulcerative Colitis, Uveitis, Vasculitis, Vitiligo

Keywords

spontaneous coronary artery dissection, autoimmune, incidence

Brief summary

This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 110 Years

Inclusion criteria

* Adults age 18 to 110 * Residence in Olmsted County. Note: if sufficient numbers cannot be reached using only Olmsted County, will expand to the 27-county region.

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame
Odds of autoimmune disease in SCAD cases compared to controls	Through study completion, or approximately 50 years (average age of study participants)
Incidence Rate of SCAD	Through study completion, or approximately 50 years (average age of study participants)

Secondary

Measure	Time frame
SCAD recurrence	Through study completion, or approximately 50 years (average age of study participants)

Other

Measure	Time frame	Description
Odds of laboratory markers for autoimmune disease in SCAD cases compared to controls	Through study completion, or approximately 50 years (average age of study participants)	—
Odds of validated rheumatoid arthritis in SCAD cases compared to controls	Through study completion, or approximately 50 years (average age of study participants)	using the Rochester Epidemiology Project Rheumatoid Arthritis cohort

Countries

United States

Outcome results