Large Segmental Bone Defect
Conditions
Brief summary
The investigators apply 3D printed titanium implant to treat bone defects. Without using bone grafts and growth factors, the investigators anticipate the titanium implant alone can help bone reconstruction.
Detailed description
The investigators treat large segmental bone defects caused by three reasons, including trauma, infection and tumor. In this study, polyporous 3D printed titanium implant is applied to reconstruct the bone defects and the investigators will follow up patients' function and bone regeneration.
Interventions
DEVICE3D printed titanium implant
The 3D printed titanium implant is fabricated by related companies. And some implants have been used in spinal disease in our hospital.
Sponsors
Peking University Third Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* bone defects caused by trauma or infection or tumor * the length of bone defect is more than 6cm * more than 18 years old
Exclusion criteria
* malignant tumor * patients with bad conditions failing to tolerate surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bone reconstruction | 1 year | X-rays and CT scans are used to evaluate the bone reconstruction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Questionnaire of limb function | 1 year | Restoration of limb function. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Questionnaire of patients' satisfaction degree | 1 year | VAS score is used to evaluate the satisfaction degree. The score ranges from 0 to 10, 0 means very dissatisfied and 10 means very satisfied. |
Countries
China
Contacts
Primary ContactBingchuan Liu, MD
Outcome results
None listed