Overweight, Postmenopausal Women
Conditions
Keywords
Interval Training, Resistance Training, Overweight, Postmenopausal women, Body composition, Gut microbiota
Brief summary
Postmenopausal women, as men, are more prone to central or android obesity than premenopausal women. Recently, some studies have shown that obesity is associated with gut microbiota dysbiosis and gut microbiota could be responsible of fat mass accumulation. Moreover, abdominal fat mass accumulation is associated with an increase of cardiovascular disease risks. Recent studies suggest that physical activity may positively alter gut microbiota composition. Accumulating evidence suggests that high intensity interval training (HIIT) is an effective strategy for reducing body fat of overweight individuals, especially at the abdominal level. Resistance Training (RT) is associated with increased muscle mass and strength gain in main muscle groups. Thus, RT is also an interesting modality to fight against deconditioning and autonomy loss with age. The aim of the study was to observed the effects of a 12-week high intensity interval training (HIIT) combined with resistance training (RT) program on gut microbiota and body composition changes in postmenopausal women. It is hypothesized that HIIT +RT will improve gut microbiota and body composition (including whole body and (intra)-abdominal fat mass) in a concomitant and parallel way.
Detailed description
The aim of the study was to observed the effects of a 12-week high intensity interval training (HIIT) combined with resistance training (RT) program on gut microbiota and body composition changes in postmenopausal women. 30 postmenopausal women will be randomly assigned to HIIT + RT (n= 15) group or Control group (n=15). HIIT+RT: Each subject performed HIIT protocol consisted of repeated 60 cycles of speeding up for 8 s followed by pedalling slowly for 12 s (20min) Then they performed a single set of 10 exercises with 1 or 2min resting period between exercises. The set consisted of 8-12 repetitions at about 80% maximum repetition (1RM). Control group : (no training program) Subjects will keep their life style. Faecal microbiota and body composition will be measured before and after the intervention (3 months). The investigators will examine the effects of HIIT + RT programs on: Body composition : total-abdominal and visceral fat mass, total fat free mass and muscle mass Faecal concentration of short chain fatty acids Total fat free mass (and appendicular fat free mass) (DEXA) Glycemic profile (plasma HbA1c, plasma glucose, plasma insulin) Lipid profile (TG, HDL, LDL, total cholesterol) Aerobic capacity (VO2 max) Muscular capacity (fatigability, isometric and dynamic strenght)
Interventions
OTHERTraining program
High Intensity Interval Training + Resistance Training (HIIT + RT)
Sponsors
CREPS Auvergne Rhône-Alpes (AURA)
Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Masking description
Data collected on the volunteers will be made anonymous.
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Postmenopausal women * BMI ≥ 25 and \< 40 * Able to follow an exercise protocol * Eating behavior and physical activity stable since at least 3 month
Exclusion criteria
* Subject not able to perform exercise after medical examination * Subject not able to perform bicycle exercise (pains) * Use of β-blocker * Medical treatment that could interfere with the different outcome measures (antibiotics) * Hormonal Replacement Therapy (HRT)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in the composition of gut microbiota | Baseline T0 and 3 months after intervention starting | Evolution of microbiota composition will be evaluated from fecal microbiota analyse before and after intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Total fat free mass | Baseline T0 and 3 months after intervention starting | Change from baseline in total fat free mass (g) (estimated from DEXA) |
| Abdominal fat mass | Baseline T0 and 3 months after intervention starting | Change from baseline in abdominal fat mass (g) (estimated from DEXA) |
| Visceral fat mass | Baseline T0 and 3 months after intervention starting | Change from baseline in visceral fat mass (g) (estimated from DEXA) |
| Concentration of Short Chain Fatty Acids (SCFAs) | Baseline T0 and 3 months after intervention starting | Short Chain Fatty Acid's concentration in faeces will be measured |
| Evolution of fasting glucose level | Baseline T0 and 3 months after intervention starting | Change from baseline in plasma fasting glucose level |
| Total fat mass | Baseline T0 and 3 months after intervention starting | Change from baseline in total fat mass (g) (estimated from DEXA) |
| Evolution of HbA1c | Baseline T0 and 3 months after intervention starting | Change from baseline in plasma HbA1c (%) |
| Evolution of lipid profile | Baseline T0 and 3 months after intervention starting | Change from baseline in plasma triglycerides, total cholesterol, LDL- and HDL cholesterol. |
| Evolution of plasma inflammatory marker | Baseline T0 and 3 months after intervention starting | Change from baseline in plasma C-Reactive Protein |
| Evolution of fitness level | Baseline T0 and 3 months after intervention starting | Change from baseline in VO2max |
| Evolution of muscular capacity | Baseline T0 and 3 months after intervention starting | Change from baseline maximal isometric strenght |
| Evolution of insulinemia | Baseline T0 and 3 months after intervention starting | Change from baseline in plasma fasting insulinemia (mmol/L) |
Countries
France
Outcome results
None listed