Parkinson's Disease, Healthy Controls Group - Age and Sex-matched
Conditions
Keywords
Biomarkers, Magnetic resonance imaging (MRI), Neuropsychology, Transcranial magnetic stimulation (TMS)
Brief summary
This study aims at identifying potential new and innovative biomarkers in de novo Parkinson's disease patients. New finding will help phenotyping patients since the diagnosis of the disease and potentially also in the preclinical phase.
Detailed description
The investigators will use 4 different approaches in parallel: 1. detailed clinical evaluation using the current available validated clinical scales and the Dopamine transporter (DAT) SPECT imaging; 2. anatomical and perfusional brain evaluation using functional MRI; 3. cortical brain mapping and transcranial magnetic stimulation assessment using a robotized approach; 4. emotional responses study using a novel paradigm. These 4 modalities will be assessed at baseline, 1 year and 2 years follow-up. The investigators will integrate these 4 analysis using a mathematical paradigm in order to define specific phenotype of disease and disease progression.
Interventions
PROCEDUREBrain MRI
3 Tesla brain MRI for structural and perfusion evaluation, resting state analysis and functional MRI
PROCEDURETMS-EEG
Transcranial magnetic stimulation (TMS) coupled with electroencephalogram (EEG) study
BEHAVIORALBehavioral and cognitive battery
Emotional, attentional and behavioral assessment using predefine scales and measures
OTHERClinical evaluation and clinical scales
Neurological evaluation, ophthalmologic assessement, Montreal cognitive assessment (MoCA), movement disorder society (MDS)- UPDRS
Sponsors
University Hospital, Clermont-Ferrand
Grenoble Institut des Neurosciences
University Hospital, Grenoble
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Parkinson's disease * Asymmetric bradykinesia and/or resting tremor and rigidity since less than 2.5 years ; * Hoehn & Yahr ≤ 2/5 ; * Montreal cognitive assessment ≥ 26/30 ;
Exclusion criteria
* Treatment for Parkinson's disease (except selegiline and rasagiline) * Severe visual/retinal pathology revealed during ophthalmological assessment * Hyper-sensibility to gadolinium * Renal failure * Specific MRI contraindication * Specific TMS contraindication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare brain perfusional differences between subjects | In a seven months period after inclusion | All subjects will have a 3 Tesla brain MRI to collect data concerning perfusion. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Pseudo-Continuous Arterial Spin Labeling (PCASL), T2 with gadolinium, FLAIR |
| To compare cortical excitability differences between subjects | In a seven months period after inclusion | The EEG data after transcranial magnetic stimulation testing will be compared between parkinsonian patients and controls |
| To compare brain structural differences between subjects | In a seven months period after inclusion | All subjects will have a 3 Tesla brain MRI to collect data concerning anatomy. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: T1 and T2, Fast Gray Matter Acquisition T1 Inversion Recovery (FGATIR) |
| To compare brain connectivity differences between subjects | In a seven months period after inclusion | All subjects will have a 3 Tesla brain MRI to collect data concerning functional connectivity at rest. All data will be compared between patients and controls. Brain MRI study will consist in having the following sequences: Echo planar imaging (EPI) for the blood oxygen level-dependent effect |
| To compare emotional, attentional and behavior differences between subject | In a seven months period after inclusion | Subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker. |
| To compare emotional, attentional and behavior differences between subject with functional MRI | In a seven months period after inclusion | During a functional MRI study, subjects will be asked to comment on different pictures (if the picture induces pleasure, sorrow or nothing; what would the subjects do). Attentional parameters will be recorded using the Eye tracker. |
Countries
France
Outcome results
None listed