Periodontal Diseases
Conditions
Keywords
Psoriasis
Brief summary
There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.
Detailed description
The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.
Interventions
OTHERPsoriatic measurements
Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.
OTHERNon-surgical periodontal treatment
Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.
OTHERsaliva samples
Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.
Sponsors
Ozge Gokturk
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* the presence at least 20 remaining teeth, * the presence of Stage I or Stage II Periodontitis, * the presence of diagnosed psoriasis.
Exclusion criteria
* patients who had the immune-inflammatory disease and require antibiotic prophylaxis, * patients who received periodontal treatment prior to 6 months, * women who were breastfeeding or pregnant, * patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proinflammatory cytokines | Baseline and after 8 weeks | The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gingival index | Baseline and after 8 weeks | The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected. |
| PASI index | Baseline and after 8 weeks | The changes in PASI index level after periodontal treatment. PASI index was measured for determining the severity of psoriasis disease. Higher values represent a worse outcome. After periodontal treatment, a reduction in PASI index value is expected. |
Countries
Turkey (Türkiye)
Outcome results
None listed