Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass
Conditions
Brief summary
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Since the potential adverse effects of hyperoxemia (via reactive oxygen species, vasocontriction, perfusion heterogeneity, myocardiac injury, etc.), various studies on this topic has been performed. However, the results are conflicting and inconsistent, and the consensus about whether the use of additional oxygen supply in cardiac surgery using CPB has not been reached among practitioners yet.
Interventions
A fraction of inspired oxygen level during cardiac surgery using cardiopulmonary bypass will be set differently: 0.5 versus 1.0.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients scheduled for cardiac surgery using cardiopulmonary bypass
Exclusion criteria
* Planned implementation of deep hypothermic circulatory arrest * Preoperative respiratory support with the fraction of inspired oxygen of 0.5 and more.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| hospital LOS | From the beginning of surgery until the hospital discharge after surgery through study completion, an expected average of two weeks | length of hospital stay after cardiac surgery using cardiopulmonary bypass |
Countries
South Korea
Outcome results
None listed