Ovarian Stimulation
Conditions
Brief summary
This study aims to study the efficiency of using a single injection of Corifollitropin alfa for ovarian stimulation by initiating administration late and without further administration of follicle-stimulating hormone after the 7th day of stimulation compared to conventional ovarian stimulation using Corifollitropin alfa (drug administration 5 days after cessation of hormonal contraceptive and supplementation with follicle-stimulating hormone daily administration from the 8th day of stimulation). This a controlled randomized clinical study and 180 patients will be recruited (90 per arm) and the primary study outcome is the number of obtained oocytes.
Interventions
The used treatment will be identical in both arms. The difference between the groups will be the moment of beginning of the stimulation as well as the later administration of more FSH activity. The control grup will receive the treatment on the 5th day after the cessation of hormonal contraceptive use. The used treatment will be identical in both arms. The difference between the groups will be the moment of beginning of the stimulation as well as the later administration of more FSH activity. The intervention grup will receive the treatment on the 7th day after the cessation of hormonal contraceptive use.
Sponsors
Instituto Bernabeu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 32 Years
Healthy volunteers
Yes
Inclusion criteria
* Eligible for oocyte donation program * Age between 18 and 32 years old * BMI \>18 and \<30 * Antral follicle count \>12 (summing both ovaries) * Presence of both ovaries * Ability to participate in and comply with study protocol * Signed informed consent * No treatment with ovulation stimulators in the 3 months prior to the start of stimulation.
Exclusion criteria
* Diagnosis of endometriosis at any stage * AFC \>20 * Polycystic ovary syndrome * Concurrent participation in another study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of oocytes | At the end of stimulation | Number of oocytes after stimulation |
Countries
Spain
Outcome results
None listed