Aerobic Exercise, Fructose Metabolism Disorder, Fructose Rich Diet, Metabolic Disease
Conditions
Brief summary
Cardiometabolic diseases have been associated with high consumption of sweetened beverages. These products are responsible for the largest portion of the total consumption of fructose in the diet and it is suggested that excessive intake of this monosaccharide may contribute to the development of risk factors for these diseases due to differences in metabolism relative to glucose. However, there is a lack of data in the literature demonstrating the deleterious effects of excessive fructose consumption on vasodilation and whether aerobic training may be able to prevent or mitigate these damages in humans. Therefore, the aim of the study will be to verify the effect of 4 weeks of high fructose diet associated with aerobic training on uric acid levels and its influence on markers related to oxidative stress and vasodilatation. Twenty-one sedentary men and women, aged between 19 and 35 years, will be submitted to 4 weeks of intervention. In a randomized way, subjects will be divided into 3 groups: high fructose diet, high glucose diet and high fructose diet and exercise. Blood samples will be taken before, in the middle and after the intervention to verify the concentrations of uric acid, superoxide dismutase enzyme, thiobarbituric acid, nitrite / nitrate, lipid profile, glucose, insulin, C-reactive protein and endothelin-1. In addition, flow-mediated dilatation, insulin resistance index, pancreatic beta cell functional capacity index, oral glucose tolerance test, 24-hour blood pressure, heart rate variability and body composition will be analyzed. The comparisons will be performed through the Generalized Estimates of Equations, adopting the factors group and time. The Bonferroni post-hoc will be used to identify differences. The accepted level of significance will be 5%.
Interventions
DIETARY_SUPPLEMENTFructose
Consumption of 1.0g / kg of body mass / day of fructose.
DIETARY_SUPPLEMENTGlucose
Consumption of 1.0g / kg of body mass / day of glucose.
OTHERFructose and exercise
Consumption of 1.0g / kg of body mass / day of fructose + 3 weekly sessions of 60 minutes of aerobic exercise.
Sponsors
Federal University of Rio Grande do Sul
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and women; * Not engaged in regular exercises; * Aged between 19 and 35 years; * Body mass index (BMI) of less than 30kg / m².
Exclusion criteria
* Individuals with BMI below 18kg / m² and greater than 30kg / m²; * Smokers; * Dyslipidemic; * Diabetic; * Hypertensive; * Alcohol use; * Appetite suppressants use; * Medications use; * Supplements use; * Chronic disease that impedes the performance of physical exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow Mediated Dilatation | 4 weeks |
| Concentration of Uric Acid | 4 weeks |
| Concentration of Nitrite / Nitrate | 4 weeks |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of Triglycerides | 4 weeks | — |
| Concentration of Low-Density Lipoprotein | 4 weeks | — |
| Concentration of High-Density Lipoprotein | 4 weeks | — |
| Concentration of Glucose | 4 weeks | — |
| Concentration of Insulin | 4 weeks | — |
| HOMA-IR | 4 weeks | — |
| Concentration of Superoxide Dismutase Enzyme | 4 weeks | — |
| Insulin Sensitivity | 4 weeks | Oral glucose tolerance test |
| Concentration of C-Reactive Protein | 4 weeks | — |
| Concentration of Endothelin-1 | 4 weeks | — |
| 24-hour Blood Pressure | 4 weeks | — |
| Heart Rate Variability | 4 weeks | — |
| Body Fat | 4 weeks | — |
| HOMA-B | 4 weeks | — |
| Concentration of Substances Reactive to Thiobarbituric Acid | 4 weeks | Oxidative stress outcome |
| Concentration of Total Cholesterol | 4 weeks | — |
Countries
Brazil
Outcome results
None listed