Metabolic and Nutritional Characteristics of Long-stayer ICU Patients

Long-stayer Critically Ill Patients: is the Metabolic and Nutritional Therapy in the ICU Creating the Problem?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03938961

Acronym

Nutri-ICU-LS

Enrollment

205

Registered

2019-05-06

Start date

2017-02-01

Completion date

2020-04-13

Last updated

2020-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically Ill

Keywords

Metabolism, Energy,Glucose, Protein, Energy deficit

Brief summary

The intensive care (ICU) patient population has increasing number of very long ICU stays. Long-stayers are usually defined as requiring more than 1 week of mechanical ventilation and of ICU therapy: little is know about their metabolic characteristics and their relation to outcome. The study aims at describing the demographic, nutritional and metabolic aspects of their stay. Analysis of 200-250 consecutive patients admitted to the ICU long-stayer program.

Detailed description

Data extracted from the computerized ICU system (PDMS): age, Simplified acute physiology score (SAPSII), weight, BMI, Nutrition Risk Score (NRS-2002), daily energy, protein, and glucose intakes, Energy balance, blood glucose (dysglycemia and Glu variability) and lactate, 24hr-insulin (Goal Glu 6-8 mmol/l). Outcome variables: length of stay (LICU), muscle strength (MRC), vital status at 90 days. Patients will be followed in detail until ICU discharge and for vital status until day 90 after admission Data will be presented as mean or median, univariate and multivariate analysis will be performed.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ICU length of stay \> 7 days and enrollment to the long-stayer ICU program

Exclusion criteria

* Major burns * Brain injury * Severe neurological condition as primary disease

Design outcomes

Primary

Measure	Time frame	Description
Vital Status	up to 90 days	Alive or dead at 90 days after ICU admission

Secondary

Measure	Time frame	Description
Force	up to 90 days	Muscle strength measured by Medical research Council (MRC) score

Other

Measure	Time frame	Description
Decubitus ulcer	up to 90 days	Appearance of decubitus ulcer during ICU stay

Countries

Switzerland

Outcome results